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Upregulation of ICAM-1 in diabetic rats after transient forebrain ischemia and reperfusion injury
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نویسنده
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jing l. ,wang j.-g. ,zhang j.-z. ,cao c.-x. ,chang y. ,dong j.-d. ,guo f.-y. ,andy li p.
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منبع
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journal of inflammation - 2014 - دوره : 11 - شماره : 1
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چکیده
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Background: hyperglycemia exacerbates brain damage caused by cerebral ischemia. neuroinflammation may play a role in mediating such enhanced damage. the objectives of this study were to examine the mrna and protein levels and cell type distribution of icam-1 after cerebral ischemia in normo-and diabetic hyperglycemic rats. results: compared to normoglycemic ischemia animals,diabetes aggravated neuronal death,decreased nissl body staining,and increased icam-1 mrna and protein levels in the frontal cortex. the increased icam-1 was located not only in vascular endothelial cells but also in cortical neurons. conclusions: our results suggest that exacerbated neuro-inflammation in the brain may mediate the detrimental effects of diabetes on the ischemic brain. © 2014 jing et al.; licensee biomed central ltd.
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کلیدواژه
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Cerebral ischemia; Endothelia; Forebrain ischemia; ICAM-1; Inflammation; Neurodegeneration; Neuron; Stroke
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آدرس
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department of pathology,ningxia medical university,ningxia key laboratory for cerebrocranial diseases,incubation base of national key laboratory,yinchuan,ningxia, China, department of pathology,ningxia medical university,ningxia key laboratory for cerebrocranial diseases,incubation base of national key laboratory,yinchuan,ningxia, China, department of pathology,ningxia medical university,ningxia key laboratory for cerebrocranial diseases,incubation base of national key laboratory,yinchuan,ningxia, China, department of pathology,ningxia medical university,ningxia key laboratory for cerebrocranial diseases,incubation base of national key laboratory,yinchuan,ningxia, China, department of pathology,ningxia medical university,ningxia key laboratory for cerebrocranial diseases,incubation base of national key laboratory,yinchuan,ningxia, China, department of pathology,ningxia medical university,ningxia key laboratory for cerebrocranial diseases,incubation base of national key laboratory,yinchuan,ningxia, China, department of pathology,ningxia medical university,ningxia key laboratory for cerebrocranial diseases,incubation base of national key laboratory,yinchuan,ningxia, China, department of pharmaceutical sciences,biomanufacturing research institute and technological enterprise (brite),north carolina central university,durham,nc, United States
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Authors
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