Absence of 4-1BB reduces obesity-induced atrophic response in skeletal muscle

Obesity-induced inflammation causes skeletal muscle atrophy accompanied by disruption of oxidative metabolism and is implicated in metabolic complications such as insulin resistance and type 2 diabetes. we previously reported that 4-1bb,a member of the tumor necrosis factor receptor superfamily,participated in obesity-induced skeletal muscle inflammation. here,we show that the absence of 4-1bb in obese mice fed a high-fat diet led to a decrease in expression of atrophic factors (murf1 and atrogin-1) with suppression of nf-κb activity,and that this was accompanied by increases in mitochondrial oxidative metabolic genes/proteins (e.g.,pgc-1α,cpt1β,etc.) expression and oxidative muscle fibers marker genes/proteins in the skeletal muscle. these findings suggest that 4-1bb-mediated inflammatory signaling could be a potential target for combating obesity-related muscle atrophy and metabolic derangement in skeletal muscle. © 2017 the author(s).