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Interleukin-35 on B cell and T cell induction and regulation
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نویسنده
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huang a. ,cheng l. ,he m. ,nie j. ,wang j. ,jiang k.
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منبع
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journal of inflammation - 2017 - دوره : 14 - شماره : 1
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چکیده
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Interleukin (il)-35 is a relatively newly discovered member of il-12 cytokine family that is unique in that it is a dimer formed by two subunits. the review documents the structure,secretion and signal transduction of il-35,the regulation effect of il-35 on b cells and t cells as well as the adoptive transfer of il-35+ regulatory b cells (breg),therapeutic prospects of recombinant il-35 (ril-35) and il-35 regulation role in various diseases. b-cell regulation expands the regulatory range of il-35 and alters the view that il-10 is the chief immune mechanism for breg cells which secrete il-35. il-35 induces breg cells,which then can induce treg cells. il-35 also plays an immunomodulatory role in the human body. © 2017 the author(s).
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کلیدواژه
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B cells; Interleukin -35; T cells
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آدرس
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department of thoracic surgery,union hospital,tongji medical college,huazhong university of science and technology,no.1277 jiefang avenue,wuhan,hubei province,430022, China, department of anesthesiology,union hospital,tongji medical college,huazhong university of science and technology,no.1277 jiefang avenue,wuhan,hubei province,430022, China, department of thoracic surgery,union hospital,tongji medical college,huazhong university of science and technology,no.1277 jiefang avenue,wuhan,hubei province,430022, China, department of thoracic surgery,union hospital,tongji medical college,huazhong university of science and technology,no.1277 jiefang avenue,wuhan,hubei province,430022, China, department of thoracic surgery,union hospital,tongji medical college,huazhong university of science and technology,no.1277 jiefang avenue,wuhan,hubei province,430022, China, department of thoracic surgery,union hospital,tongji medical college,huazhong university of science and technology,no.1277 jiefang avenue,wuhan,hubei province,430022, China
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Authors
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