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Hypertensive epigenetics: from DNA methylation to microRNAs
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نویسنده
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Wang J ,Gong L ,Tan Y ,Hui R ,Wang Y
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منبع
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journal of human hypertension - 2015 - دوره : 29 - شماره : 10 - صفحه:575 -582
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چکیده
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The major epigenetic features of mammalian cells include dna methylation, posttranslational histone modifications and rna-based mechanisms including those controlled by small non-coding rnas (micrornas (mirnas)). an important aspect of epigenetic mechanisms is that they are potentially reversible and may be influenced by nutritional–environmental factors and through gene–environment interactions. studies on epigenetic modulations could help us understand the mechanisms involved in essential hypertension and further prevent it’s progress. this review is focused on new knowledge on the role of epigenetics, from dna methylation to mirnas, in essential hypertension.
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آدرس
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Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, Sino-German Laboratory for Molecular Medicine, China, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, Sino-German Laboratory for Molecular Medicine, China, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, Sino-German Laboratory for Molecular Medicine, China, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, Sino-German Laboratory for Molecular Medicine, China, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Cardiovascular Disease, Sino-German Laboratory for Molecular Medicine, China
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Authors
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