Renal sympathetic denervation: effect on ambulatory blood pressure and blood pressure variability in patients with treatment-resistant hypertension. the ReShape CV-risk study

Renal sympathetic denervation (rdn) represents a potential treatment option for highly selected patients with resistant arterial hypertension. in this open label study, we aimed to investigate the response of blood pressure (bp) and short-term bp variability (bpv) to rdn 6 months after procedure. we defined treatment-resistant hypertension as office systolic bp>140 mm hg, despite maximum tolerated doses of ⩾4 antihypertensive drugs, including a diuretic. in addition, daytime systolic ambulatory blood pressure (abpm) >135 mm hg was required after witnessed intake of antihypertensive drugs. bilateral rdn was performed with the symplicity catheter system (n=23). the mean systolic office bp and abpm fell from 162±20 mm hg to 139±19 mm hg (p<0.001) and from 154±20 mm hg to 144±16 mm hg (p<0.038), respectively. in addition, we observed a significant reduction in diastolic office bp and abpm. the current study also demonstrated a significant decrease of both systolic and diastolic average real variability, weighted standard deviation (s.d.) as well as conventional s.d. of mean and daytime bp, but not of s.d. of nighttime bp. rdn after witnessed intake of ⩾4 antihypertensive drugs reduced both office bp and abpm at 6 months in patients with truly resistant hypertension. also bpv improved, possibly reflecting an additional effect from intervening on the sympathetic nerve system.