>
Fa   |   Ar   |   En
   Desphospho-uncarboxylated matrix Gla protein is associated with increased aortic stiffness in a general population  
   
نویسنده Jr O Mayer ,Seidlerová J ,Wohlfahrt P ,Filipovský J ,Vaněk J ,Cífková R ,Windrichová J ,Topolčan O ,Knapen M H J ,Drummen N E A ,Vermeer C
منبع journal of human hypertension - 2016 - دوره : 30 - شماره : 7 - صفحه:418 -423
چکیده    Matrix gla protein (mgp), a natural inhibitor of calcification, strongly correlates with the extent of coronary calcification. vitamin k is the essential cofactor for the activation of mgp. the nonphosphorylated-uncarboxylated isoform of mgp (dp-ucmgp) reflects the status of this vitamin. we investigated whether there is an association between dp-ucmgp and stiffness of elastic and muscular-type large arteries in a random sample from the general population. in a cross-sectional design, we analyzed 1087 subjects from the czech post-monica study. aortic and femoro-popliteal pulse wave velocities (pwvs) were measured using a sphygmocor device. dp-ucmgp concentrations were assessed in freshly frozen samples by enzyme-linked immunosorbent assay methods using the inaktif mgp isys pre-commercial kit developed by ids and vitak. aortic pwv significantly (p<0.0001) increased across the dp-ucmgp quartiles. after adjustment for all potential confounders, aortic pwv independently correlated with dp-ucmgp (with beta coefficient (s.d.) 11.61 (5.38) and p-value=0.031). in a categorized manner, subjects in the top quartile of dp-ucmgp (⩾ 671 pmol l−1) had a higher risk of elevated aortic pwv, with corresponding adjusted odds ratio (95% confidence interval) 1.73 (1.17–2.5). in contrast, no relation between dp-ucmgp and femoro-popliteal pwv was found. in conclusion, increased dp-ucmgp, which is a circulating biomarker of vitamin k status and vascular calcification, is independently associated with aortic stiffness, but not with stiffness of distal muscular-type arteries.
آدرس Medical Faculty of Charles University and University Hospital, 2nd Department of Internal Medicine, Czech Republic. Medical Faculty of Charles University, Czech Republic, Medical Faculty of Charles University and University Hospital, 2nd Department of Internal Medicine, Czech Republic. Medical Faculty of Charles University, Czech Republic, Charles University and Thomayer Hospital, Czech Republic. St. Anne’s University Hospital, Czech Republic, Medical Faculty of Charles University and University Hospital, 2nd Department of Internal Medicine, Czech Republic. Medical Faculty of Charles University, Czech Republic, Medical Faculty of Charles University and University Hospital, 2nd Department of Internal Medicine, Czech Republic, Charles University and Thomayer Hospital, Czech Republic. St. Anne’s University Hospital, Czech Republic, University Hospital, Department of Immunodiagnostics, Czech Republic, University Hospital, Department of Immunodiagnostics, Czech Republic, Maastricht University, Maastricht, Maastricht University, Maastricht, Maastricht University, Maastricht
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved