Different combinations of glucose tolerance and blood pressure status and incident cardiovascular disease and all-cause mortality events

The purpose of this study was to evaluate the effect of combinations of blood pressure and glucose tolerance status on cardiovascular and all-cause mortality. a total of 7619 participants aged ⩾30 years old were stratified to nine categories as follows: (1) normotension (ntn) and normal glucose tolerance (ngt) (reference group), (2) ntn and pre-diabetes mellitus (pre-dm), (3) ntn and dm, (4) pre-hypertension (pre-htn) and ngt, (5) pre-htn and pre-dm, (6) pre-htn and dm, (7) htn and ngt, (8) htn and pre-dm and (9) htn and dm. cox proportional hazards were applied to calculate the multivariate hazard ratios (hrs) of different groups for outcomes. for all-cause mortality outcomes, prevalent cardiovascular disease (cvd) was also adjusted. in a median follow-up of 11.3 years, 696 cvd and 412 all-cause mortality events occurred. among the population free from cvd at baseline (n=7249), presence of htn was associated with increased risk of cvd, regardless of glucose tolerance status with hrs of 1.97 (95% confidence interval (ci), 1.49–2.61), 2.25 (1.68–3.02) and 3.16 (2.28–4.37) for phenotypes of htn and ngt, htn and pre-dm and htn and dm for cvd, respectively; corresponding hrs for all-cause mortality were 1.65 (95% ci, 1.15–2.37), 1.69 (1.15–2.49) and 2.73 (1.80–4.14), respectively. phenotypes of ntn and pre-dm (1.48; 1.03–2.14) and ntn and dm (2.04; 1.06–3.92) were also associated with cvd and all-cause mortality, respectively. htn was significantly associated with cvd/mortality events, regardless of glucose tolerance status. blood pressure <120/80 mm hg among pre-diabetic/diabetic population, not on antihypertensive medications, was generally associated with worse outcomes.