The donor ABCB1 (MDR-1) C3435T polymorphism is a determinant of the graft glomerular filtration rate among tacrolimus treated kidney transplanted patients

The abcb1 gene encodes the p-glycoprotein (p-gp) that drives the transmembrane efflux of many drugs. the donor abcb1 polymorphisms have been related with chronic histological damage and long-term renal function among kidney transplanted patients who received cyclosporine a and tacrolimus (tac). the aim of our study was to determine whether the donor abcb1 3435 c/t genotype was related with renal function among tac-treated renal transplanted patients. kidney donors (n=65) and recipients (n=90) were genotyped for the abcb1 rs1045642 (c.3435 c/t) and cyp3a5 rs776746 single-nucleotide polymorphisms. the estimated glomerular filtration rate (egfr) was calculated with the modification of diet in renal disease formulae at five post-transplant times (2 weeks and 1, 3, 6 and 12 months). the recipient abcb1 and cyp3a5 genotypes had no significant effect on the egfr at all the post-transplant times. we found significantly lower egfr values among patients who received a kidney from abcb1 3435 t carriers (p<0.01). in conclusion, our study confirmed the potential impact of the donor abcb1 3435 genotype on the post-transplant renal function among patients treated with tac.