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Genome-wide association study of IgA nephropathy using 23 465 microsatellite markers in a Japanese population
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نویسنده
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Saka Sanae ,Hirawa Nobuhito ,Oka Akira ,Yatsu Keisuke ,Hirukawa Takeshi ,Yamamoto Ryohei ,Matsusaka Taiji ,Imai Enyu ,Narita Ichiei ,Endoh Masayuki ,Ichikawa Iekuni ,Umemura Satoshi ,Inoko Hidetoshi
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منبع
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journal of human genetics - 2015 - دوره : 60 - شماره : 10 - صفحه:573 -580
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چکیده
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Immunoglobulin a nephropathy (igan) is the most common form of primary glomerulonephritis in many parts of the world. although previous genome-wide association studies (gwas) identified the major susceptibility loci for igan, the causal genes currently remain unknown. we performed a gwas using 23 465 microsatellite (ms) markers to identify genes related to igan in a japanese population. a pooled sample analysis was conducted in three-stage screenings of three independent case–control populations, and after the final step of individual typing, 11 markers survived. of these, we focused on two regions on 6p21 and 12q21 because they (i) showed the strongest relationship with igan, and (ii) appeared to be highly relevant to igan in view of several previous studies. these regions contained the hla, tspan8 and ptprr genes. this study on gwas, using >20 000 ms markers, provides a new approach regarding susceptible genes for igan for investigators seeking new tools for the prevention and treatment of igan.
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آدرس
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Yokohama City University, Department of Medical Science and Cardiorenal Medicine, Japan. Yokohama City University Medical Center, Department of Nephrology and Hypertension, Japan, Yokohama City University Medical Center, Department of Nephrology and Hypertension, Japan, Tokai University, Japan, Yokohama City University, Department of Medical Science and Cardiorenal Medicine, Japan, Tokai University School of Medicine, Division of Nephrology, Department of Internal Medicine, Japan, Osaka University Graduate School of Medicine, Department of Nephrology, Japan, Tokai University School of Medicine, Division of Nephrology, Department of Internal Medicine, Japan, Nakayamadera Imai Clinic, Japan. Fujita Health University, Department of Nephrology, Japan, Niigata University Graduate School of Medical and Dental Sciences, Japan, Tokai University School of Medicine, Division of Nephrology, Department of Internal Medicine, Japan, Department of Ethics, Shinshu Univeristy, Japan. Vanderbilt University, Departments of Pediatrics and Medicine, USA, Yokohama City University, Department of Medical Science and Cardiorenal Medicine, Japan, Tokai University, Japan
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Authors
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