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Gene–environment interactions in obesity: implication for future applications in preventive medicine
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نویسنده
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Nakamura Sho ,Narimatsu Hiroto ,Sato Hidenori ,Sho Ri ,Otani Katsumi ,Kawasaki Ryo ,Karasawa Shigeru ,Daimon Makoto ,Yamashita Hidetoshi ,Kubota Isao ,Ueno Yoshiyuki ,Kato Takeo ,Yoshioka Takashi ,Fukao Akira ,Kayama Takamasa
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منبع
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journal of human genetics - 2016 - دوره : 61 - شماره : 4 - صفحه:317 -322
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چکیده
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Obesity is associated with environmental factors; however, information about gene–environment interactions is lacking. we aimed to elucidate the effects of gene–environment interactions on obesity, specifically between genetic predisposition and various obesity-related lifestyle factors, using data from a population-based prospective cohort study. the genetic risk score (grs) calculated from east asian ancestry single-nucleotide polymorphisms was significantly associated with the body mass index (bmi) at baseline (p<0.001). significant gene–environment interactions were observed for six nutritional factors, alcohol intake, metabolic equivalents-hour per day and the homeostasis model assessment ratio. the grs altered the effects of lifestyle factors on bmi. increases in the bmi at baseline per unit intake for each nutritional factor differed depending on the grs. however, we did not observe significant correlations between the grs and annual changes in bmi during the follow-up period. this study suggests that the effects of lifestyle factors on obesity differ depending on the genetic risk factors. the approach used to evaluate gene–environment interaction in this study may be applicable to the practice of preventive medicine.
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آدرس
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Yamagata University, Japan, Yamagata University, Department of Public Health, Japan. Kanagawa Cancer Center Research Institute, Cancer Prevention and Control Division, Japan, Yamagata University, Genome Informatics Unit, Japan, Yamagata University, Department of Public Health, Japan, Yamagata University, Department of Public Health, Japan, Yamagata University, Department of Public Health, Japan, Yamagata University, Third Department of Internal Medicine, Japan, Hirosaki University, Department of Endocrinology and Metabolism, Japan, Yamagata University, Department of Ophthalmology and Visual Sciences, Japan, Yamagata University, First Department of Internal Medicine, Japan, Yamagata University, Second Department of Internal Medicine, Japan, Yamagata University, Third Department of Internal Medicine, Japan, Yamagata University, Japan, Yamagata University, Department of Public Health, Japan, Yamagata University, Department of Advanced Cancer Science, Japan
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Authors
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