Two genetic variants in telomerase-associated protein 1 are associated with stomach cancer risk

This study examined the impact of two single-nucleotide polymorphisms (snps) in the telomerase-associated protein 1 (tep1) gene on the risk of breast, colorectal, hepatocellular, lung and stomach cancer. a significantly increased stomach cancer risk associated with the gg genotype at rs1760893 (odds ratio (or)=1.64, 95% confidence interval (ci)=1.23–2.20, p=0.004) or cc genotype at rs1713423 (or=2.40, 95% ci=1.88–3.07, p<0.0001) was observed, compared with their wild-type counterpart. the gg genotype at rs1760893 was also associated with enhanced hepatocellular cancer susceptibility (or=1.46, 95% ci=1.05–2.03, p=0.02). in classification and regression tree analysis, individuals carrying the cc genotype at rs1713423 had 2.69-fold increased risk of stomach cancer (95% ci=2.18–3.32, p<0.0001) compared with the tt and tc genotypes. the current results suggested that genetic variants at tep1 snps rs1760893 and rs1713423 may be associated significantly with increased risk of stomach cancer.