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Shared genetic variants for polypoidal choroidal vasculopathy and typical neovascular age-related macular degeneration in East Asians
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نویسنده
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Fan Qiao ,Cheung Chui Ming Gemmy ,Chen Li Jia ,Yamashiro Kenji ,Ahn Jeeyun ,Laude Augustinus ,Mathur Ranjana ,Mun Chan Choi ,Yeo Ian Y ,Lim Tock Han ,Teo Yik-Ying ,Khor Chiea Chuen ,Park Kyu-Hyung ,Yoshimura Nagahisa ,Pang Chi Pui ,Wong Tien Yin ,Cheng Ching-Yu
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منبع
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journal of human genetics - 2017 - دوره : 62 - شماره : 12 - صفحه:1049 -1055
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چکیده
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Polypoidal choroidal vasculopathy (pcv), a subtype of age-related macular degeneration (amd) more frequently seen in east asians, has both common and distinct clinical manifestations with typical neovascular amd (tamd). we aim to examine the extent to which common genetic variants are shared between these two subtypes. we performed the meta-analysis of association in a total of 1062 pcv patients, 1157 tamd patients and 5275 controls of east asian descent from the genetics of amd in asians consortium at the 34 known amd loci. a total of eight loci were significantly associated with pcv, including age-related maculopathy susceptibility 2 (arms2)-htra serine peptidase 1 (htra1), complement factor h (cfh), c2-cfb-skiv2l, cetp, vegfa, adamts9-as2 and tgfbr1 (p<5 × 10−4) from the single-nucleotide polymorphism-based test and col4a3 from the gene-based tests (pgene=2.02 × 10−4). pcv and tamd are genetically highly correlated (rg=0.69, p=4.68 × 10−3), with amd known loci accounting for up to 36% variation. weaker association for pcv was observed at arms2-htra1 (pdif=4.39 × 10−4) and kmt2e-srpk2(pdif=4.43 × 10−3), compared with tamd. variants at cfh, cetp and vegfa exhibited different association signals in east asians, in contrast to those in european individuals. our data suggest a substantially shared genetic susceptibility for pcv and tamd, while also highlight the unique associations for pcv, which is useful in understanding the pathogenesis of pcv.
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آدرس
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Duke-NUS Medial School, Singapore, Singapore National Eye Center, Singapore. Duke-NUS Medical School, Singapore, The Chinese University of Hong Kong, Department of Ophthalmology and Visual Sciences, China, Kyoto University Graduate School of Medicine, Department of Ophthalmology and Visual Sciences, Japan, Seoul National University Bundang Hospital, Department of Ophthalmology, Korea, Tan Tock Seng Hospital, Singapore, Singapore National Eye Center, Singapore. Duke-NUS Medical School, Singapore, Singapore National Eye Center, Singapore, Singapore National Eye Center, Singapore, Tan Tock Seng Hospital, Singapore, National University of Singapore and National University Health System, Singapore. National University of Singapore, Department of Statistics and Applied Probability, Singapore. Agency for Science, Singapore, Singapore National Eye Center, Singapore. Agency for Science, Singapore, Seoul National University Bundang Hospital, Department of Ophthalmology, Korea, Kyoto University Graduate School of Medicine, Department of Ophthalmology and Visual Sciences, Japan, The Chinese University of Hong Kong, Department of Ophthalmology and Visual Sciences, China, Singapore National Eye Center, Singapore. Duke-NUS Medical School, Singapore. National University of Singapore, Department of Ophthalmology, Singapore, Singapore National Eye Center, Singapore. Duke-NUS Medical School, Singapore. National University of Singapore, Department of Ophthalmology, Singapore
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Authors
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