comparison of efficacy of pipelle biopsy with dilatation and curettage

Background: to compare efficacy of pipelle biopsy as an office biopsy method with dilatation curettage (d&c) for women referring ali ebn e abitaleb hospital of zahedan university of medical science in 2015 - 2016. methods: in this cross sectional study, 200 patients with abnormal uterine bleeding (aub) who had referred to gynecology clinic of ali ebn e abitaleb hospital of zahedan university of medical science, were selected. the patients were randomly allocated to the two groups based on permuted block design method. in 1th group (n = 100), pipelle biopsy was performed as office biopsy and 2th group (n = 100), dilatation curettage (d&c) was performed in operation room. sampling was done by the same surgeon and was interpreted by the same pathologist. results: the samples were adequate in 1th group (n = 88), 88% and in 2th group (n = 98) 98%. fisher test was used for statistical analysis. it reported statistical significant difference between pipelle biopsy and dilatation curettage (d&c) in terms of histopathology and samples efficacy (p = 0.01). conclusions: obtained results demonstrated that efficacy of pipelle biopsy is high. totally this procedure is safe and cost-effective with low complications. however, we should be careful to alternate pipelle biopsy instead of dilatation-curettage (d&c) in aub approach.