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Acute Lymphoblastic Leukemia in Two Patients with B-Thalassemia Major
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نویسنده
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Naderi Majid ,Miri-Moghaddam Ebrahim ,Alizadeh Shaban ,Dorgalaleh Akbar ,Tabibian Shadi
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منبع
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zahedan journal of research in medical sciences - 2014 - دوره : 16 - شماره : 11 - صفحه:50 -51
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چکیده
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Occurrence of leukemia in thalassemia major is a rare presentation. here we report two cases of thalassemic patients, developing acute lymphoblastic leukemia. the genetic analysis revealed that, female and male patients were homozygous for ivsi-6 and ivsi-5, respectively. two years ago the female patient presented by a high leukocyte count (154,000 µl) and male one also presented by 80,000 wbc/µl count 1 year ago. microscopic examination of both patients revealed lymphoblasts that morphologically accommodate with all-l1 that were confirmed by photocytometry.
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کلیدواژه
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Thalassemia major ,Leukemia ,Transfusion
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آدرس
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zahedan university of medical sciences, Department of Pediatrics, Research Center for Children and Adolescents Health, Zahedan University of Medical Sciences, Zahedan, Iran, ایران, zahedan university of medical sciences, Department of Genetics, Genetics of Non-Communicable Disease Research Centre, Zahedan University of Medical Sciences, Zahedan, Iran, ایران, tehran university of medical sciences tums, Department of Hematology, Tehran University of Medical Sciences, Tehran, Iran, ایران, tehran university of medical sciences tums, Department of Hematology, Tehran University of Medical Sciences, Tehran, Iran, ایران, tehran university of medical sciences tums, Department of Hematology, Tehran University of Medical Sciences, Tehran, Iran, ایران
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Authors
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