Effect of Amonium Vanadate Nano-Particles on Experimental Diabetes and Biochemical Factors in Male Spargue-Dawly Rats

Background: vanadium compounds have antidiabetic, but there is no study about the antidiabetic effects of ammonium monovanadate nono-particles. in this study, antidiabetic effect of ammonium monovanadate was compared with its nonoparticles.materials and methods: in this experimental and animal modeling study, 42 male sprague dawley rats were divided in 6 groups (each group 7 rats). diabetes was induced by ip injection of 60 mg/kg streptozicin to five groups. one normal group and one diabetic group were kept without treatment as control groups. other diabetic rats were treated with nonovanadate 25 mg/kg (nv25), ordinary vanadate 25 mg/kg (v25), nonovanadate 15 mg/kg (nv15) and water ordinary vanadate 25 mg/kg (wv25) groups for 10 days by gavage. heparinized blood was collected at days 11 and 21 and centrifuged to separate plasma. glycosylated hemoglobin, insulin, triglyceride (tg), total cholesterol (tc), hdl-c and ldl-c were measured at both time and compared between groups.results: all treatment except in v25 decreased glycemia, but insulin increased only in nv25 group (p < 0.05). all treatment decreased tg, tc and ldl-c significantly (p < 0.001).conclusion: ammonium mono vanadate nonoparticle has better effects than ordinary ammonium mono vanadate on some biochemical factors in experimental diabetes.