Comparison Between the Effects of the Alcholic Extract of Mellissia Officinalis and Atorvastatin on Serum Levels of Thyroid Hormones in Hypercholesterolemic Male Rats

Background: consumption of unsaturated fats reduces the serum level of lipids and leptin. thyroid hormones and leptin play pivotal roles in metabolism and their amounts are inter-related. this study was done to compare the effects of mellissia officinalis extract and atorvastatin on the serum levels of thyroid hormones in hypercholesterolemia rats.materials and methods: consumption of unsaturated fats reduces the serum level of lipids and leptin. thyroid hormones and leptin play pivotal roles in metabolism and their amounts are inter-related. this study was done to compare the effects of mellissia officinalis extract and atorvastatin on the serum levels of thyroid hormones in hypercholesterolemia rats.results: the results showed that in experimental groups receiving the plant extract and atorvastatin, the concentration of thyroid hormones increased, whereas the amount of the thyroid-stimulating hormone showed a significant decrease (p < 0.05).conclusion: mellissia officinalis extract decreases tsh but it increases t3 and t4. further studies are required for applying this extract to the treatment of hyperthyroidism.