advances in management methods for convulsive status epilepticus in children: a review of iran algorithms

Context :as a common disorder, convulsive status epilepticus (cse) in adults is second common and in children is most common neurological emergency. morbidity of this condition such as difficulties of learning, de-novo epilepsy and neuro-disability, could be more than twenty two percent. the higher cse duration led to higher difficulty to terminate this condition, and increase risk of morbidity. evidence acquisition :convulsive status epilepticus is often managed by specific local or national algorithms. treatment in first line is used when a focal motor clonic or tonic clonic seizure has duration more than five minutes (premonitory or impending cse). in casese who cse persisted with 2 first-line doses (difiened as cse that is established), the second-line is administered. different evidence of randomised clinical trial (rct) supports benzodiazepines use as first-line drug. in addition alternative drugs, with less data of rct studies, are intravenous clonazepam and intramuscular midazolam. results :up until 2019, phenytoin and phenobarbital were preferable second-line drug, but there are not significant rct data about it. also, lacosamide is alternative second-line agent but without supporting evidence from rct studies. current data showed that first, intravenous lorazepam or intranasal or buccal midazolam are most effective first-line drug to manage premonitory or impending cse there are not diversity between effectiveness of phenytoin, sodium valproate or levetiracetam, for management of established cse. conclusions :in present review study, we give a general overview of status epilepticus and evaluate algorithms therapy in iran.