Evaluation of Chemoprevention Effect of Systemic Celecoxib on Induction of

Background: cyclo-oxygenase-2 (cox-2) specific inhibitors were examined for predication or treatment of different tumors and it is indicated that cox-2 specific inhibitors play an important regulatory role in apoptosis of tumoral tissues. therefore, the present study was designed in order to examine the preventive effects of a cox-2 specific inhibitor called celecoxib on 4-nitroquinoline 1-oxide (4nqo)-induced squamous cell carcinoma on rat. materials and methods: in this experimental study, 30 sprague dawley rats (with the age of 3- 3.5 months) were selected and divided into three groups. in order to induce lingual carcinoma, 4nqo powder was prepared 3 times a week for each cage. in this study, celecoxib power was mixed with a basic food (basal diet) in order to examine the systematic effect. tongue samples were sent to laboratory for immunohistochemical (ihc) staining and histological examination.results: based on morphological criteria and the ratio of apoptosis to cell proliferation, the prevalence of tongue precancerous lesions was reduced significantly by celecoxib.conclusion: celecoxib systematic has inhibitory effects on the 4-nitroquinoline 1-oxide (4nqo)-induced squamous cell carcinoma of tongue. the effect of celecoxib is probably via suppression of cell proliferation and induction of apoptosis.