The Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats

Background: amyloid beta (1-42) is derived from amyloid precursor protein and plays a critical role in ad pathogenesis. the purpose of this study was to investigate the effect of 6 weeks of voluntary wheel running on brain amyloid beta (1-42) in the diabetic rats induced with alloxan. materials and methods: 28 male rats weight 185±1 were assigned randomly to 4 groups (n=7): normal control (c), training (t), control-diabetic (cd) and diabetic-training (dt). diabetes was induced with injecting alloxan (120 mg/kg dissolved in saline) intraperitoneal. results: 6 weeks of voluntary wheel running decreased the cortex ab1-42 in t and dt groups. ab1-42 levels significantly decreased in the t and dt in compare with c and cd (p < 0.001), respectively. also ab1-42 levels significantly increased in the cd in compare with c (p < 0.001).conclusion: voluntary exercise had positive effects on decreasing of ab1-42 levels during 6 weeks. therefore it can be recommended as therapeutic strategy for diabetes.