antibiotic susceptibility of klebsiella pneumonia isolates from hospitalized patients in three referral medical centers in isfahan, iran

Background: klebsiella pneumoniae(k. pneumoniae) is a major cause of nosocomial and community-acquired infections (cais). understanding the antibiotic susceptibility of this bacterium is essential for selecting the most effective antibiotic for associated infections.objectives: we investigated the sensitivity of k. pneumonia (kp) isolates obtained from inpatients in isfahan, iran. methods: organism identification and antibiotic susceptibility testing were conducted using standard tests. stratification was performed based on extended spectrum beta-lactamase (esbl) production and the source of infection acquisition (community versus hospital). results: a total of 437 kp isolates were investigated, of which 5.5% were pan drug resistant (pdr), 56.8% were extensively drug resistant (xdr), and 18% were esbl producers. the isolates were most susceptible to colistin (100%), aminoglycosides (62.8%), and carbapenems (55%). nosocomial isolates showed lower sensitivity to most of the examined antibiotics. conclusions: the high prevalence of pdr and xdr kp strains in hospitalized patients is a major problem in the studied area.