Enhancement of Serum Myonectin Levels by Progressive Resistance Training in Rats Fed with High-Fat Diet and Sucrose Solution

Background: myonectin (ctrp15) is a newly discoveredmyokine with important metabolic functions. it wasshownthat circulating myonectin levels decreased in obesity. objectives: the present study investigated the effect of 8 weeks of progressive resistance training (prt) on serum myonectin levels in rats following a high-fat diet plus sucrose solution. methods: a total of 32 male wistar rats were randomly divided into high-fat diet plus sucrose (hfds) and standard diet (sd) groups. after 12 weeks, each group was divided into sedentary and training groups. the animals in training groups were subjected to a prt program (3 days/week, for 8 weeks). flexor hallucis longus (fhl) and gastrocnemius muscle weights, epididymal and retroperitoneal fat weights, serum glucose, insulin, myonectin, and homeostasis model assessment of insulin resistance (homa-ir) were measured in this study. results: the results of the study revealed that hfds increased weight gain, fat weight, serum glucose, and homa-ir levels and decreased muscle weights and serum myonectin levels. eight weeks of prt increased serum myonectin levels and fhl and gastrocnemius muscle weights and decreased retroperitoneal fat weight. conclusions: the results suggest that prt may be an efficient intervention to enhance serum myonectin levels, which is associated with the improvement of body composition.