exercise training enhances expression of tropomedulin-2 and adp-ribosylation factor 6 in the cerebellum of male wistar rats

Background: it has been well documented that exercise training (et) induces beneficial effects on the central nervous system (cns); however, the underlying mechanisms are less known. we presumed that actin cytoskeleton regulatory proteins such as adpribosylation factors 6 (arf6) and tropomodulin 2 (tmod2) may be important elements of exercise-induced neuroplasticity (ein). we evaluated this hypothesis in the present study. methods: we randomly divided 12 male wistar rats into control (c) and training (t) groups. the t group was exposed to six weeks of moderate-intensity treadmill running. the arf6 and tmod2 gene and protein expressions in the cerebellum of male wistar rats were assessed by the real-time pcr and western blot analysis. results: the results showed that tmod2 and arf6 gene and protein expressions were significantly higher in the t group than in the c group. conclusions: it seems that chronic treadmill running increases tmod2 and arf6 gene and protein expressions in the cerebellum and these changes probably lead to the improvement of brain function.