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effect of acute and chronic administration of methimazole on morphine withdrawal signs in adult male mice
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نویسنده
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kesmati mahnaz ,gholami khadijeh ,kazeminejad s. reza
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منبع
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zahedan journal of research in medical sciences - 2015 - دوره : 17 - شماره : 2 - صفحه:60 -62
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چکیده
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Background: opioid receptors change in cns by anti thyroid hormones drugs. in this study effect of acute and chronic methimazole (amtz and cmtz) administration on morphine withdrawal were investigated. materials and methods: in this experimental study adult male mice divided into control and experimental groups receiving amtz or cmtz. all groups were addicted to morphine and morphine withdrawal was induced by naloxone and jumping, rearing and climbing signs were evaluated. results: acute mtz and chronic mtz increased the climbing and jumping (p<0.01, p<0.001). cmtz was more potent than the acute one. conclusion: mtz probably influences an opioid abstinence directly and/or indirectly through decrement of thyroid hormones.
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کلیدواژه
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mtz ,morphine withdrawal syndrome ,opioid receptors
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آدرس
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shahid chamran university, faculty of sciences, department of biology, iran, shahid chamran university, faculty of sciences, department of biology, iran, shahid chamran university, faculty of sciences, department of genetic, iran
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Authors
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