heart atp-binding cassette protein a1 and g1, peroxisome proliferator-activated receptor-α and liver x receptors genes expression in response to intensive treadmill running and red crataegus pentaegyna (sorkh valik) in male rats

Background: the heart has a very high energy demand and to sustain sufficient atp generation, can use a variety of different carbon substrates as energy sources if available. objectives: the purpose of the current study was to investigate the effect of a high intensity treadmill running training (8 weeks) with or without aqueous extraction of crataegus pentaegyna (sorkh valik) on heart abca1, abcg1, pparα and lxr genes expression. materials and methods: in this experimental study, 20 wistar male rats (4-6 weeks old, 158.9 ± 9.59 g weight) were used. animals were randomly assigned into saline-control (sc, n = 5), saline-training (st, n = 5), sorkh valik-control (svc, n = 5) and sorkh valik-training (svt, n = 5) groups. training groups have performed a high intensity running program 34 m/min on a motor-driven treadmill for 8 weeks. animals were fed orally with sorkh valik extraction (500 mg/kg) and saline solution for last 6 weeks. seventy two hours after the last training session, rats were sacrificed, heart were excised, cleaned and immediately frozen in liquid nitrogen and stored at -70°c until rna extraction. statistical analysis was performed using a two way anova, and significance was accepted at p < 0.05. results: changes in abca1 and abcg1 gene expression were not significant and a non-significant increase in ppar-α and lxr genes expression were found in the trained rats and sorkh valik-control group than in the control group. conclusions: the findings indicate that training and sorkh valik extraction solely were able to increase non-significantly all selected genes expression in rat heart. it seems that exercise with sorkh valik supplementation trend to decrease mentioned genes expression.