a survey on the frequency of hla-b27 in patients engaged with seronegative spondyloarthropathies in kashan, iran

Background: seronegative spondyloarthropathies (snsas) are referred to a group of diseases with same clinical and genetic features. objectives: due to lack of data about hla-b27 prevalence in patient with snsa in kashan this study was conducted to determine the status of hla-b27 in these patients. patients and methods: this cross sectional study was conducted on 294 patients suffered from snsa. presence or absence of hla-b27 was checked by serological method using greener kit. results were analyzed with spss-16 software using t-test and χ^2 test. results: of all 26.5% of subjects were hla-b27 positive. hla-b27 was significantly more frequent in male patients (34.1% vs. 16.5%, p < 0.001). prevalence of hla-b27 was 69% in ankylosing spondylitis, 31.5% in psoriatic arthritis, 18.2% in entropathic arthropathy, 17.9% in undifferentiated spondyloarthropathies, 16.1% in reactive arthritis and 12.5% in juvenile rheumatoid arthritis (p < 0.001). conclusions: hla-b27 has highest prevalence in ankylosing spondylitis and least prevalence in juvenile rheumatoid arthritis. hla-b27 prevalence was in relation with gender, type of disease, family history, peripheral, and axial joints engagement.