effect of coenzyme q10 supplementation on exercise-induced response of oxidative stress and muscle damage indicators in male runners

Background: heavy exercise cause muscle damage associated with very-high production of free radicals. the aim of this research was to evaluate the effect of acute and 14-day coenzyme q10 supplementation on oxidative stress and muscle damage indicator in elite male middle-distance runners. materials and methods: in this experimental study, 18 male runners in a randomly and double-blind design were allocated in two equal groups: supplement q10 group (n = 9, coenzyme q10: 5 mg/kg/day) and placebo group (n = 9, dextrose: 5 mg/kg/day). before and after supplementation acute and 14 days period (first and 14th day supplementation), all subjects were participated in a training like running (competitive 3000 meters). blood samples were obtained in the 4 phases: one hour before and 18 - 24 hours after two running protocols. malondialdehyde (mda), total antioxidation capacity (tac) and lactate dehydrogenase (ldh) were analyzed. results: acute (1 day) and 14 days (short-term) coenzyme q10 administration have not significant effect on basal parameters. the 14 days coenzyme q10 supplementation induced increase of the basal plasma total anti-oxidative capacity (p < 0.05). the short-term coenzyme q10 supplementation attenuated the exercise-induced increase in response of mda in male group q10 (p < 0.05). however, the acute and short-term coenzyme q10 supplementation had not any significant effect on the exercise-induced increase response of total serum ldh. conclusions: this research suggests that the 14-day coenzyme q10 supplementation is more effective than the acute supplementation to overcome the exercise-induced adverse responses in some oxidative, and biochemical parameters. therefore, short-term coenzyme q10 supplementation is recommended to reduce exercise-induced adverse consequences.