prevalence of alpha and beta-thalassemia mutations among carriers of thalassemia in shadegan city, southwest of iran

Background: we aimed to investigate the alpha and beta-thalassemia mutations and assess the association of hematologic indices with mutations. patients and methods: in this cross sectional study, we assessed 275 suspected thalassemia carriers. amplification refractory mutation system-polymerase chain reaction and gap pcr were used for detection of mutations. results: cd 36 - 37 (-t) and -α3.7/αα were most common mutations. mean of corpuscular hemoglobin and corpuscular volume was less among beta-thalassemia carriers in comparison to alpha-thalassemia carriers (p = 0.001). conclusions: detected mutations were different from other regions in iran. after iron therapy, mean of corpuscular volume (mcv) was < 69 fl and mean of corpuscular hemoglobin was < 23 pg, may be classified as beta-thalassemia carriers.