effects of aqueous extract of purslane (portulaca oleracea) on hepatic enzymes in two models of renal ischemia-reperfusion injury in rats

Objectives: this study investigated the effect of purslane on hepatic enzymes following renal ischemia-reperfusion (ir) injury in rats by two methods. materials and methods: in this experimental study, 36 male wistar rats randomly divided into 6 groups (n = 6): i) previously nephrectomized control, ii) simultaneously nephrectomized control, iii) previously nephrectomized + ir, iv) simultaneously nephrectomized + ir, v) previously nephrectomized treated by aqueous extract of p. oleracea l. + ir, vi) simultaneously nephrectomized treated by aqueous extract of p. oleracea l. + ir control and ischemia-reperfusion groups received vehicle and treatment groups received aqueous extract of purslane (300 mg/kg). in model 1, the right kidney was nephrectomized, 20 days prior to experiment, in model 2; nephrectomy was done just before induction of 45 minutes ischemia and 24 hours reperfusion to the left kidney. results: hepatic enzymes were elevated after induction of ischemia reperfusion. administration of purslane decreased hepatic enzymes. conclusions: purslane prevented liver damage more effectively in simultaneously nephrectomized model.