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distribution of egfr r521k polymorphism in different iranian ethnic groups
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نویسنده
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shahrokhshahi asal ,houshmand massoud
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منبع
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zahedan journal of research in medical sciences - 2016 - دوره : 18 - شماره : 4 - صفحه:1 -3
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چکیده
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Background: the r521k polymorphism of egfr has attenuated function in ligand binding, tyrosine kinase activation, and growth stimulation. objectives: we initiated a study to examine r521k polymorphism in six iranian ethnic groups. patients and methods: this cohort study was designed on 300 iranian healthy individuals and analyzed by pcr-rflp protocol. results: the frequencies of a/a, g/a, g/g genotype were 7.7%, 53.6% and 38.7% respectively. conclusions: no subject with a/a genotype was detected in kurds and lures. the higher frequencies of a/a genotype in arab and caspian groups compared to fars and turks could be a key determinant of better response to anticancer drugs and favorable prognosis of crc patients.
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کلیدواژه
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colorectal cancer ,epidermal growth factor receptor ,r521k polymorphism ,iranian ethnic groups
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آدرس
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islamic azad university, pharmaceutical sciences branch, faculty of advanced sciences and technology, department of molecular and cellular sciences, iran, national institute of genetic engineering and biotechnology, department of medical genetics, iran
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پست الکترونیکی
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massoudh@nigeb.ac.ir
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Authors
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