three coagulation related mutations and increased risk of myoma in women of fars province

Background: myoma is one of the most common benign tumor in the women’s genital tract and causing some implications such as miscarriages, anemia or even infertility. since tumorigenesis is associated with a hypercoagulant state, we investigate the role of coagulation related variations in methylene-tetra hydrofolate reductase (mthfr) and endothelial protein c receptor (epcr) genes in patients with uterine myoma. methods: in this case- control study, genotyping was performed for rs867186, rs1801131 and rs1801133 by amplification-refractory mutation system- polymerase chain reaction (arms-pcr) method in 73 patients withmyoma and 73 healthy women. data was analyzed by logistic regression and 2 test through software spss 16. results: a statistically significant difference was observed between patients and the control group regarding the frequency of allele c in the mthfr (a1298c) gene (p = 0.01). the frequency of the genotypes carries at least one c allele (cc + ac) is higher in patients (13.7%) compared to controls (2.7%). this means the c allele increases the risk of the disease (p = 0.01). although the frequency of the t allele in patients was higher than controls, no significant relationship was observed between it and the risk of the disease. our studied population was completely homogeneous for allele a at epcr locus. conclusions: in conclusion, results revealed a significant association between a1298t variation and myoma incidence, but more research is needed to verify the role of this mutation as a genetic marker in uterine myoma.