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efficacy of afatinib in a previously-treated patient with non-small cell lung cancer harboring her2 mutation: case report
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نویسنده
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park c.k. ,hur j.y. ,choi c.-m. ,kim t.-o. ,cho h.-j. ,shin h.-j. ,lim j.-h. ,choi y.-d. ,kim y.-c. ,oh i.-j.
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منبع
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journal of korean medical science - 2018 - دوره : 33 - شماره : 1
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چکیده
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Human epidermal growth factor receptor 2 (her2) mutation in non-small cell lung cancer (nsclc) is an oncogenic driver that possibly becomes a druggable target to her2-targeted therapy. the benefit of her2-targeted therapy is much less defined especially in eastern populations. we provide evidence of clinical benefit of afatinib in a 50-year-old asian woman with her2-mutant nsclc who previously failed cytotoxic chemotherapy and gefitinib treatment. next-generation sequencing of the tumor tissue revealed a her2 exon 20 mutation (c.2437a > g), which has never been reported. the patient was treated with afatinib for more than four months. she showed rapid radiologic response within a month, and maintained stable state until the last dose of afatinib.
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کلیدواژه
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afatinib ,her2 mutation ,non-small cell lung cancer
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آدرس
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chonnam national university hwasun hospital, lung and esophageal cancer clinic, department of internal medicine, south korea, konkuk university hospital, department of pathology, south korea, university of ulsan, asan medical center, college of medicine, department of oncology, south korea, chonnam national university hwasun hospital, department of internal medicine, south korea, chonnam national university hwasun hospital, lung and esophageal cancer clinic, department of internal medicine, south korea, chonnam national university hwasun hospital, department of internal medicine, south korea, chonnam national university hwasun hospital, lung and esophageal cancer clinic, department of internal medicine, south korea, chonnam national university medical school, lung and esophageal cancer clinic, south korea. chonnam national university, medical school, department of pathology, south korea, chonnam national university hwasun hospital, lung and esophageal cancer clinic, department of internal medicine, south korea, chonnam national university hwasun hospital, lung and esophageal cancer clinic, department of internal medicine, south korea
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Authors
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