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plasma microrna-21, 26a, and 29a-3p as predictive markers for treatment response following transarterial chemoembolization in patients with hepatocellular carcinoma
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نویسنده
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kim s.s. ,cho h.j. ,nam j.s. ,kim h.j. ,kang d.r. ,won j.h. ,kim j. ,kim j.k. ,lee j.h. ,kim b.h. ,lee m.y. ,cho s.w. ,cheong j.y.
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منبع
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journal of korean medical science - 2018 - دوره : 33 - شماره : 1
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چکیده
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Background: we investigated an association between the levels of plasma microrna (mirna)-21, -26a, and -29a-3p and treatment outcomes following transarterial chemoembolization (tace) in patients with hepatocellular carcinoma (hcc). methods: a total of 198 patients with tace-treated hcc were followed up for tace refractoriness and liver transplantation (lt)-free survival. pretreatment plasma mirna-21, -26a, and -29a-3p levels were measured using quantitative real-time polymerase chain reaction. results: during the mean follow-up of 22.3 (range, 0.7-79) months, 118 (59.6%) patients exhibited tace refractoriness. multivariate analyses showed that expression of a specific combination of mirnas (mirna-21 ≥ 2.5, mirna-26a ≥ 1.5, and mirna-29a-3p < 0.4) was associated with early tace refractoriness (within 1 year; hazard ratio [hr], 2.32; 95% confidence interval [ci], 1.08-4.99; p = 0.031) together with tumor size (hr, 4.62; 95% ci, 1.50-14.21; p = 0.008), and macrovascular invasion (hr, 3.80; 95% ci, 1.19-12.20; p = 0.025). however, mirna-21, -26a, and -29a-3p levels were not significantly associated with overall tace refractoriness or lt-free survival. additionally, large tumor size and macrovascular invasion were common predictive factor of overall tace refractoriness and survival. conclusion: combination of plasma mirna-21, -26a, and -29a-3p expression could predict early tace refractoriness in patients with tace-treated hcc.
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کلیدواژه
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carcinoma ,chemoembolization ,chronic ,hepatitis b ,hepatocellular ,micrornas ,therapeutic
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آدرس
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ajou university, school of medicine, department of gastroenterology, south korea, ajou university, school of medicine, department of gastroenterology, south korea, ajou university, human genome research and bio-resource center, medical center, south korea, ajou university, office of biostatistics, school of medicine, south korea, yonsei university, center of biomedical data science, wonju college of medicine, south korea, ajou university, school of medicine, department of radiology, south korea, ajou university, school of medicine, department of radiology, south korea, ajou university, school of medicine, department of radiology, south korea, ajou university, school of medicine, department of radiology, south korea, ajou university, school of medicine, department of radiology, south korea, ajou university, school of medicine, department of gastroenterology, south korea, ajou university, school of medicine, department of gastroenterology, south korea, ajou university, school of medicine, department of gastroenterology, south korea
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Authors
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