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Drug-susceptibility Patterns of Mycobacterium tuberculosis in Mpumalanga Province,South Africa: Possible Guiding Design of Retreatment Regimen
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نویسنده
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green e. ,obi c.l. ,nchabeleng m. ,de villiers b.e. ,sein p.p. ,letsoalo t. ,hoosen a.a. ,bessong p.o. ,ndip r.n.
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منبع
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journal of health, population and nutrition - 2010 - دوره : 28 - شماره : 1 - صفحه:7 -13
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چکیده
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Multidrug-resistant tuberculosis (mdr-tb) has been a cause of concern in both developed and developing countries. the prevalence of drug resistance in mycobacterium tuberculosis (mtb) isolates (n=692) from mpumalanga province was assessed. in total,692 (64%) mtb strains from cases with pulmonary tb were tested for susceptibility against rifampicin,isoniazid,ethambutol,and streptomycin using the mgit 960 instrument. two hundred and nine (30.2%) strains were resistant to one or more drugs. resistance to one drug ranged from 1.4% for ethambutol to 17.7% for rifampicin. the prevalence of mdr-tb ranged from 6.7% for three drugs to 34% for four drugs,with significant predictors being patients' age-groups of 25-54 years (p=0.0012) and >55 years (p=0.007). the result showed a high level (58.4%) of mdr-tb from cases in mpumalanga province. to achieve a higher cure rate in this province,drug-susceptibility tests must be done for every case. © international centre for diarrhoeal disease research,bangladesh.
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کلیدواژه
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Drug resistance; Microbial; Mycobacterium tuberculosis; Risk factors; South Africa; Tuberculosis
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آدرس
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aids virus research laboratory,department of microbiology,university of venda,south africa,department of biochemistry and microbiology,university of fort hare,private bag x1314, South Africa, research and academic directorate,walter sisulu university, South Africa, deparment of medical microbiology, South Africa, deparment of medical microbiology, South Africa, deparment of medical microbiology, South Africa, deparment of medical microbiology, South Africa, deparment of medical microbiology, South Africa, aids virus research laboratory,department of microbiology, South Africa, department of biochemistry and microbiology,university of fort hare,private bag x1314,alice 5700,south africa,department of biochemistry and microbiology, Cameroon
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Authors
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