>
Fa   |   Ar   |   En
   Maternal–infant biomarkers of prenatal exposure to arsenic and manganese  
   
نویسنده Rodrigues Ema G ,Kile Molly ,Dobson Christine ,Amarasiriwardena Chitra ,Quamruzzaman Quazi ,Rahman Mahmuder ,Golam Mostofa ,Christiani David C
منبع journal of exposure science and environmental epidemiology - 2015 - دوره : 25 - شماره : 6 - صفحه:639 -648
چکیده    Because arsenic (as) and manganese (mn) are able to pass the placenta, infants among exposed populations may be exposed to considerable levels in utero. the main objective of this paper is to evaluate infant toenails, hair, and cord blood as biomarkers of prenatal exposure to as and mn and determine the relationship between maternal and infant as and mn concentrations in these biomarkers. of the 1196 pregnant women in bangladesh who were monitored throughout pregnancy until 1 month post-partum and completed all study visits, we included 711 mother–infant pairs who had at least one maternal and one infant biomarker of exposure available for analysis. toenail and hair samples were collected from the women during the first trimester and 1 month post-partum and from the infants at the age of 1 month. cord blood was collected at the time of delivery. maternal toenail concentrations were correlated with infant toenail concentrations for as and mn (n=258, r=0.52, 95% ci: 0.43–0.60, p<0.0001 and r=0.39, 95% ci: 0.28–0.49, p<0.0001), respectively. similarly, maternal hair concentrations were correlated with infant hair as (n=685, r=0.61, 95% ci: 0.56–0.65, p<0.0001) and infant hair mn (n=686, r=0.21, 95% ci: 0.14–0.28, p<0.0001). cord blood as was correlated with infant toenail and hair as, although cord blood mn was only correlated with infant toenail. toenails and cord blood appear to be valid biomarkers of maternal–fetal transfer of as and mn, whereas hair may not be a suitable biomarker for in utero exposure to mn.
آدرس Harvard School of Public Health, Department of Environmental Health, USA, Oregon State University, Department of Public Health, USA, Harvard School of Public Health, Department of Environmental Health, USA, Icahn School of Medicine at Mount Sinai, Department of Preventive Medicine, USA, Dhaka Community Hospital, Bangladesh, Dhaka Community Hospital, Bangladesh, Dhaka Community Hospital, Bangladesh, Harvard School of Public Health, Department of Environmental Health, USA
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved