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   Epidemiological analysis of the association between hearing and barium in humans  
   
نویسنده Ohgami Nobutaka ,Mitsumatsu Yuji ,Ahsan Nazmul ,Akhand Anwarul Azim ,Li Xiang ,Iida Machiko ,Yajima Ichiro ,Naito Mariko ,Wakai Kenji ,Ohnuma Shoko ,Kato Masashi
منبع journal of exposure science and environmental epidemiology - 2016 - دوره : 26 - شماره : 5 - صفحه:488 -493
چکیده    Our previous study experimentally showed barium (ba)-mediated hearing loss in mice. to our knowledge, however, it remains unknown whether ba affects hearing in humans. this epidemiological study aimed at investigating ototoxicity of ba in humans. associations of ba levels in hair, toenails and urine with hearing levels (1, 4, 8 and 12 khz) were analyzed in 145 bangladeshi subjects. binary logistic regression analysis with adjustment for age, sex, body mass index (bmi) and smoking showed that ba levels in hair had significant associations with hearing loss at 8 khz (or=4.75; 95% ci: 1.44, 17.68) and 12 khz (or=15.48; 95% ci: 4.04, 79.45). ba levels in toenails were also associated with hearing loss at 8 khz (or=3.20; 95% ci: 1.35, 7.85) and 12 khz (or=3.63; 95% ci: 1.58, 8.55), whereas there was no correlation between ba level in urinary samples and hearing. there was a significant correlation between hearing loss and ba levels in hair and toenails in the model adjusted with arsenic levels as the confounder. in conclusion, this study suggested that ba levels could be a new risk factor for hearing loss, especially at high frequencies of 8 and 12 khz, in humans.
آدرس Nagoya University Graduate School of Medicine, Department of Occupational and Environmental Health, Japan. Chubu University, Japan. Voluntary Body for International Health Care in Universities, Japan, Nagoya University Graduate School of Medicine, Department of Occupational and Environmental Health, Japan, University of Dhaka, Department of Genetic Engineering and Biotechnology, Bangladesh, University of Dhaka, Department of Genetic Engineering and Biotechnology, Bangladesh, Nagoya University Graduate School of Medicine, Department of Occupational and Environmental Health, Japan, Nagoya University Graduate School of Medicine, Department of Occupational and Environmental Health, Japan. Chubu University, Japan. Voluntary Body for International Health Care in Universities, Japan, Nagoya University Graduate School of Medicine, Department of Occupational and Environmental Health, Japan. Voluntary Body for International Health Care in Universities, Japan, Nagoya University Graduate School of Medicine, Department of Preventive Medicine, Japan, Nagoya University Graduate School of Medicine, Department of Preventive Medicine, Japan, Voluntary Body for International Health Care in Universities, Japan, Nagoya University Graduate School of Medicine, Department of Occupational and Environmental Health, Japan. Voluntary Body for International Health Care in Universities, Japan
 
     
   
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