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   Urinary metabolites of 1-nitropyrene in US–Mexico border residents who frequently cross the San Ysidro Port of Entry  
   
نویسنده Galaviz Vanessa Eileen ,Quintana Penelope Jane Eiddwen ,Yost Michael George ,Sheppard Lianne ,Paulsen Michael Henry ,Camp Janice Ellouise ,Simpson Christopher David
منبع journal of exposure science and environmental epidemiology - 2017 - دوره : 27 - شماره : 1 - صفحه:84 -89
چکیده    Diesel exhaust presents a community exposure hazard, but methods to measure internal exposure are lacking. we report results from a community-based study using 1-nitropyrene (1-np) and its urinary metabolites as markers of exposure to traffic-related diesel particulate matter (dpm). the study participants were tijuana, mexico residents who commuted on foot into san diego, california for work or school using the international san ysidro port of entry, placing them within feet of idling traffic (referred to as border commuters). the comparison group (non-border commuters) was comprised of residents of south san diego who did not commute into mexico. air concentration of 1-np in fine particulate matter (pm2.5) was measured in personal samples from participants. spot urine samples were analyzed for 1-np urinary metabolites 8-hydroxy-1-nitropyrene (8-ohnp) and 8-hydroxy-n-acetyl-1-aminopyrene (8-ohnaap). compared with non-border commuters, border commuters had two- to threefold higher mean urinary concentrations for unadjusted and creatinine-adjusted 8-ohnp and 8-ohnaap. urinary 8-ohnaap and the sum of 8-ohnp and 8-ohnaap were both associated with personal exposure to 1-np in the prior 24 h. these results suggest that 1-np urinary metabolites reflect recent exposure to dpm-derived 1-np in community settings and can be useful for exposure analysis.
آدرس University of Washington, Department of Environmental and Occupational Health Sciences, USA. California Environmental Protection Agency, USA, San Diego State University, USA, University of Washington, Department of Environmental and Occupational Health Sciences, USA, University of Washington, Department of Environmental and Occupational Health Sciences, Department of Biostatistics, USA, University of Washington, Department of Environmental and Occupational Health Sciences, USA, University of Washington, Department of Environmental and Occupational Health Sciences, USA, University of Washington, Department of Environmental and Occupational Health Sciences, USA
 
     
   
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