|
|
Maternal/fetal metabolomes appear to mediate the impact of arsenic exposure on birth weight: A pilot study
|
|
|
|
|
نویسنده
|
Wei Yongyue ,Shi Qianwen ,Wang Zhaoxi ,Zhang Ruyang ,Su Li ,Quamruzzaman Quazi ,Rahman Mahmuder ,Chen Feng ,Christiani David C
|
منبع
|
journal of exposure science and environmental epidemiology - 2017 - دوره : 27 - شماره : 3 - صفحه:313 -319
|
چکیده
|
Arsenic exposure has been associated with low birth weight. however, the underlying mechanisms are not well understood. alterations to metabolites may act as causal mediators of the effect of arsenic exposure on low birth weight. this pilot study aimed to explore the role of metabolites in mediating the association of arsenic exposure on infant birth weight. study samples were selected from a well-established prospectively enrolled cohort in bangladesh comprising 35 newborns and a subset of 20 matched mothers. metabolomics profiling was performed on 35 cord blood samples and 20 maternal peripheral blood samples collected during the second trimester of pregnancy. inorganic arsenic (ias) exposure was evaluated via cord blood samples and maternal toenail samples collected during the first trimester. multiple linear regression and mediation analyses were used to explore the relationship between ias exposure, metabolite alterations, and low birth weight. cord blood arsenic level was correlated with elevated levels of 17-methylstearate, laurate (12:0) and 4-vinylphenol sulfate along with lower birth weight. prenatal maternal toenail ias level was associated with two peripheral blood metabolites (butyrylqlycine and tartarate), which likely contributed to higher cord blood ias levels both independently and interactively. findings of this pilot study indicate that both intrauterine and maternal peripheral blood metabolites appear to influence the toxic effect of inorganic arsenic exposure on low birth weight.
|
|
|
آدرس
|
Ministry of Education Key Laboratory for Modern Toxicology, Nanjing Medical University, Department of Biostatistics, China. Harvard School of Public Health, Department of Environmental Health, USA. Nanjing Medical University School of Public Health/Harvard School of Public Health, Joint Laboratory of Health and Environmental Risk Assessment (HERA), China, Ministry of Education Key Laboratory for Modern Toxicology, Nanjing Medical University, Department of Biostatistics, China, Harvard School of Public Health, Department of Environmental Health, USA, Ministry of Education Key Laboratory for Modern Toxicology, Nanjing Medical University, Department of Biostatistics, China. Harvard School of Public Health, Department of Environmental Health, USA. Nanjing Medical University School of Public Health/Harvard School of Public Health, Joint Laboratory of Health and Environmental Risk Assessment (HERA), China, Harvard School of Public Health, Department of Environmental Health, USA, Dhaka Community Hospital, Bangladesh, Dhaka Community Hospital, Bangladesh, Ministry of Education Key Laboratory for Modern Toxicology, Nanjing Medical University, Department of Biostatistics, China. Nanjing Medical University School of Public Health/Harvard School of Public Health, Joint Laboratory of Health and Environmental Risk Assessment (HERA), China, Harvard School of Public Health, Department of Environmental Health, USA. Nanjing Medical University School of Public Health/Harvard School of Public Health, Joint Laboratory of Health and Environmental Risk Assessment (HERA), China. Massachusetts General Hospital/Harvard Medical School, Department of Medicine, USA
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|