The association of 18F-deoxyglucose (FDG) uptake of PET with polymorphisms in the glucose transporter gene (SLC2A1) and hypoxia-related genes (HIF1A,VEGFA,APEX1) in non-small cell lung cancer. SLC2A1 polymorphisms and FDG-PET in NSCLC patients

Background. positron emission tomography imaging of lung cancers with 2-[fluorine-18]-fluoro-2-deoxy-d-glucose is a non-invasive diagnostic,and prognostic tool that measures tumor metabolism. we have analyzed the effect of solute carrier family 2 (facilitated glucose transporter),member 1 polymorphisms on 2-[fluorine-18]-fluoro-2-deoxy-d-glucose-uptake with a combination of polymorphisms of hypoxia-inducible factor 1 alpha,apurinic/apyimidinic endonuclease,and vascular endothelial growth factor a in a hypoxia-related pathway. methods. we investigated the association between solute carrier family 2 (facilitated glucose transporter),member 1 -2841at,hypoxia-inducible factor 1 alpha pro582ser,ala588thr,apurinic/apyimidinic endonuclease asp148glu,or vascular endothelial growth factor a +936ct and 2-[fluorine-18]-fluoro-2-deoxy-d-glucose-uptake among 154 patients with non-small-cell lung cancer. results. the solute carrier family 2 (facilitated glucose transporter),member 1 -2841at polymorphism was significantly associated with 2-[fluorine-18]-fluoro-2-deoxy-d-glucose-uptake in combination with the apurinic/apyimidinic endonuclease asp148glu (tg) polymorphism in the squamous cell type of non-small-cell lung cancer. the solute carrier family 2 (facilitated glucose transporter),member 1 tt genotype had a higher maximum standardized uptake values than the aa + at genotype when the apurinic/apyimidinic endonuclease genotype was tt (mean maximum standardized uptake values,12.47 1.33 versus 8.46 2.90,respectively; p = 0.028). the mean maximum standardized uptake values were not statistically different with respect to vascular endothelial growth factor a and hypoxia-inducible factor 1 alpha polymorphisms. conclusion. a glucose transporter gene polymorphism was shown to be statistically associated with glucose-uptake when the apurinic/apyimidinic endonuclease genotype is tt in patients with the squamous cell type of non-small-cell lung cancer. our findings suggest that a newly developed tracer for positron emission tomography could be affected by genetic polymorphisms. © 2010 kim et al; licensee biomed central ltd.