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Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma
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نویسنده
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ye f. ,yu y. ,hu y. ,lu w. ,xie x.
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منبع
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journal of experimental and clinical cancer research - 2010 - دوره : 29 - شماره : 1
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چکیده
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Patients with cervical carcinoma (cc) are frequently immunocompromised. dendritic cells (dcs) are potent antigen-presenting cells. using multicolor flow cytometry,the percentages of cd11c+ (dc1) and cd123+ (dc2) subsets,were determined in the peripheral blood of 37 patients with cervical carcinoma (cc),54 patients with cin,and 62 healthy individuals. a substantial reduction of circulating dendritic cells and accordingly immunodepression may be associated with increased il-6 and tgf- in serum. these findings could give expression to the immunosuppression of circulating dendritic cells in patients with cc and cin,thus,may indicate novel aspects of cervical carcinoma immune evasion. © 2010 feng et al; licensee biomed central ltd.
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آدرس
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women's reproductive health key laboratory of zhejiang province,zhejiang university,women's hospital,xueshi rd#2,hangzhou 310006, China, department of gynecologic oncology,zhejiang university,women's hospital,xueshi rd#2,hangzhou,310006, China, women's reproductive health key laboratory of zhejiang province,zhejiang university,women's hospital,xueshi rd#2,hangzhou 310006, China, department of gynecologic oncology,zhejiang university,women's hospital,xueshi rd#2,hangzhou,310006, China, department of gynecologic oncology,zhejiang university,women's hospital,xueshi rd#2,hangzhou,310006, China
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Authors
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