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MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs
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نویسنده
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du l. ,schageman j.j. ,irnov division of basic sciences ,girard l. ,hammond s.m. ,minna j.d. ,gazdar a.f. ,pertsemlidis a.
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منبع
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journal of experimental and clinical cancer research - 2010 - دوره : 29 - شماره : 1
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چکیده
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Background: recent studies have shown that micrornas (mirnas) play roles in umorigenesis and are reliable classifiers of certain cancer types and subtypes. however,the role of mirnas in the pathogenesis and diagnosis of small cell carcinoma (sclc),the majority of which represent the most aggressive lung tumors,has not been investigated. methods. in order to explore mirna involvement in the pathogenesis of small cell lung carcinoma (sclc) and the potential role of mirnas in sclc diagnosis,we compared the mirna expression profile of a set of sclc cell lines to that of a set of non-small cell lung cancer (nsclc) cell lines and normal immortalized human bronchial epithelial cells (hbecs) using microarray analysis. results. our results show that mirna profiles reliably distinguish sclc cell lines from nsclc and hbec cell lines. further analysis of the mirna expression profile of the two subtypes of lung cancer cell lines indicates that the expression levels of the majority of the mirnas that are differentially expressed in sclc cells relative to nsclc cells and hbecs show a progressive trend from hbecs to nsclc cells to sclc cells. conclusions. the distinctive mirna expression signature of sclcs relative to nsclcs and hbecs suggests that mirna profiles have the potential to serve as a diagnostic marker of sclc lung tumors. the progressive trend of mirna profile changes from hbecs to nsclcs to sclcs suggests a possible pathological relationship between sclcs and nsclcs,and suggests that the increasing dysregulation of mirna expression may play a role in lung tumor progression. the specific role of these mirnas in lung tumor pathogenesis and differentiation need to be investigated further in future studies. © 2010 du et al; licensee biomed central ltd.
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آدرس
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simmons comprehensive cancer center,ut southwestern medical center,dallas,tx, United States, mcdermott center for human growth and development,ut southwestern medical center,dallas,tx, United States, southwestern graduate school of biomedical sciences,ut southwestern medical center,dallas,tx, United States, hamon center for therapeutic oncology research,ut southwestern medical center,dallas,tx,united states,department of pharmacology,ut southwestern medical center,dallas,tx, United States, lineberger comprehensive cancer center,school of medicine,university of north carolina,chapel hill,nc, United States, simmons comprehensive cancer center,ut southwestern medical center,dallas,tx,united states,hamon center for therapeutic oncology research,ut southwestern medical center,dallas,tx,united states,department of pharmacology,ut southwestern medical center,dallas,tx,united states,department of internal medicine,ut southwestern medical center,dallas,tx, United States, simmons comprehensive cancer center,ut southwestern medical center,dallas,tx,united states,hamon center for therapeutic oncology research,ut southwestern medical center,dallas,tx,united states,department of pathology,ut southwestern medical center,dallas,tx, United States, simmons comprehensive cancer center,ut southwestern medical center,dallas,tx,united states,hamon center for therapeutic oncology research,ut southwestern medical center,dallas,tx,united states,department of internal medicine,ut southwestern medical center,dallas,tx, United States
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Authors
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