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The association between ATM D1853N polymorphism and breast cancer susceptibility: A meta-analysis
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نویسنده
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gao l.-b. ,pan x.-m. ,sun h. ,wang x. ,rao l. ,li l.-j. ,liang w.-b. ,lv m.-l. ,yang w.-z. ,zhang l.
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منبع
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journal of experimental and clinical cancer research - 2010 - دوره : 29 - شماره : 1
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چکیده
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Background: emerging evidence suggests that ataxia telangiectasia-mutated (atm) is involved in numerous damage repair signaling pathways and cell-cycle checkpoints. heterozygous carriers of atm-mutations have an increased risk for the development of breast cancer. the purpose of this study is to evaluate the association between atm exon39 5557g > a (d1853n,rs1801516) polymorphism and breast cancer susceptibility with the use of a meta-analysis. methods: by searching pubmed and embase databases,a total of 9 epidemiological studies with 4,191 cases and 3,780 controls were identified. crude odds ratios (ors) and their corresponding 95% confidence intervals (cis) for atm d1853n polymorphism and breast cancer risk were calculated using fixed-or random-effects model based on the degree of heterogeneity among studies. results: no significant association between the atm d1853n polymorphism and breast cancer risk was observed in overall analysis (ga versus gg: or = 1.18; 95% ci,0.90-1.53; aa versus gg: or = 0.77; 95% ci,0.58-1.03; dominant model: or = 1.16; 95% ci,0.89-1.51; and recessive model: or = 0.78; 95% ci,0.59-1.04,respectively). conclusion: our results indicate that atm d1853n polymorphism is not a risk factor for developing breast cancer. © 2010 gao et al; licensee biomed central ltd.
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آدرس
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laboratory of molecular translational medicine,west china second university hospital,sichuan university,chengdu,sichuan 610041, China, department of forensic pathology,henan university of science and technology,luoyang,henan 471003,china,department of forensic biology,west china school of preclinical and forensic medicine,sichuan university,chengdu,sichuan 610041, China, department of immunology,west china school of preclinical and forensic medicine,sichuan university,chengdu,sichuan 610041, China, laboratory of molecular translational medicine,west china second university hospital,sichuan university,chengdu,sichuan 610041, China, department of cardiology,west china hospital,sichuan university,chengdu,sichuan,610041, China, department of forensic biology,west china school of preclinical and forensic medicine,sichuan university,chengdu,sichuan 610041, China, department of forensic biology,west china school of preclinical and forensic medicine,sichuan university,chengdu,sichuan 610041, China, department of immunology,west china school of preclinical and forensic medicine,sichuan university,chengdu,sichuan 610041, China, department of pathology,college of preclinical medicine,dali university,dali,yunnan,671000, China, laboratory of molecular translational medicine,west china second university hospital,sichuan university,chengdu,sichuan 610041, China
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Authors
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