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Elevated c-Src and c-Yes expression in malignant skin cancers
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نویسنده
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lee j.h. ,pyon j.-k. ,kim d.w. ,lee s.h. ,nam h.s. ,kim c.h. ,kang s.g. ,lee y.j. ,park m.y. ,jeong d.j. ,cho m.k.
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منبع
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journal of experimental and clinical cancer research - 2010 - دوره : 29 - شماره : 1
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چکیده
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Background: src family kinases (sfks) play an important role in cancer proliferation,survival,motility,invasiveness,metastasis,and angiogenesis. among the sfks,c-src and c-yes are particularly over-expressed or hyper-activated in many human epithelial cancers. however,only a few studies have attempted to define the expression and role of c-src and c-yes in cutaneous carcinomas. objectives. to investigate the expression of c-src and c-yes in cutaneous carcinomas to include malignant melanoma (mm),squamous cell carcinoma (scc) and basal cell carcinoma (bcc). methods: we examined 6 normal skin tissues and 18 malignant skin tumor tissues using western blotting for the expression of c-src and c-yes. in another set,16 specimens of mm,16 sccs and 16 bccs were analyzed for the expression of c-src and c-yes using immunohistochemical staining. results: western blotting showed that c-src was expressed in all malignant skin tumors,but not in normal skin,while c-yes was expressed in mm and scc,but not in bcc and normal skin. immunohistochemical staining results of c-src and c-yes in mm,scc,and bcc mirrored those of the western blot analysis. conclusions: c-src,rather than c-yes,plays a key role in the proliferation and progression of malignant skin cancers. © 2010 lee et al; licensee biomed central ltd.
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آدرس
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department of plastic and reconstructive surgery,hanyang university,guri hospital,guri, South Korea, department of plastic and reconstructive surgery,school of medicine,sungkyunkwan university,seoul, South Korea, molecular cancer research center,college of medicine,soonchunhyang university,chunan, South Korea, molecular cancer research center,college of medicine,soonchunhyang university,chunan, South Korea, molecular cancer research center,college of medicine,soonchunhyang university,chunan, South Korea, molecular cancer research center,college of medicine,soonchunhyang university,chunan, South Korea, molecular cancer research center,college of medicine,soonchunhyang university,chunan, South Korea, molecular cancer research center,college of medicine,soonchunhyang university,chunan, South Korea, department of dermatology,national medical center,seoul, South Korea, molecular cancer research center,college of medicine,soonchunhyang university,chunan, South Korea, molecular cancer research center,college of medicine,soonchunhyang university,chunan,south korea,department of dermatology,college of medicine,soonchunhyang university,seoul, South Korea
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Authors
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