A study of association between expression of hOGG1,VDAC1,HK-2 and cervical carcinoma

Background. human 8-oguanine glycosylase 1(hogg1),voltage-dependent anion channel 1(vdac1),hexokinase 2(hk-2),represented the process of oxidative dna damage,cell apoptosis and glycolysis,respectively. this study aims to explore the association between expression of hogg1,vdac1,hk-2 and cervical carcinoma. methods. a case-control study was conducted. 65 cervical biopsy samples consist of 20 control and 45 cases. the expression of hogg1,vdac1 and hk-2 were examined with immunohistochemistry(ihc),immunolabeling was evaluated with stereological cell counts. results. the data showed that the positive proportion of hogg1 and hk-2 in the case group was higher than that of the control group (p < 0.05). further,there was an increasing trend for the positive proportion and expression degree of hogg1 and hk-2 from control,mild cervical carcinoma (mcc),intermediate cervical carcinoma(icc) to severe cervical carcinoma(scc) in order (p < 0.05). to vdac1,the significant result was not obtained. conclusions. the results suggested that there was a close association between expression of hogg1,hk-2 and cervical cancer. hogg1 and hk-2 might play a key role at the early stage of cervical cancer,and the findings of hogg1 and hk-2 should be considered as a significant biomarker at the early stage of cervical cancer. © 2010 guo-qing et al; licensee biomed central ltd.