|
|
|
|
Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs
|
|
|
|
|
|
|
|
نویسنده
|
pasche b. ,wisinski k.b. ,sadim m. ,kaklamani v. ,pennison m.j. ,zeng q. ,bellam n. ,zimmerman j. ,yi n. ,zhang k. ,baron j. ,stram d.o. ,hayes m.g.
|
|
منبع
|
journal of experimental and clinical cancer research - 2010 - دوره : 29 - شماره : 1
|
|
چکیده
|
Purpose. constitutively decreased tgfbr1 allelic expression is emerging as a potent modifier of colorectal cancer risk in mice and humans. this phenotype was first observed in mice,then in lymphoblastoid cell lines from patients with microsatellite stable colorectal tumors. patients and methods. we assessed the frequency of constitutively decreased tgfbr1 allelic expression and association with snps covering the tgfbr1 locus using rna and dna extracted from the peripheral blood lymphocytes of 118 consecutive patients with biopsy-proven adenocarcinoma of the colon or the rectum. results: we found that 11(9.3%) of 118 patients exhibited decreased tgfbr1 allelic expression (tgfbr1 ase). tgfbr1 ase was strongly associated with three snps in linkage disequilibrium with each other: rs7034462 (p = 7.2 × 10-4),tgfbr1*6a (p = 1.6 × 10-4) and rs11568785 (p = 1.4 × 10-4). conclusion: these results confirm the high prevalence of constitutively decreased tgfbr1 allelic expression among patients with colorectal cancer. the association of this phenotype with tgfbr1*6a,rs7034462 and rs1156875 suggests an association between tgfbr1 snps and colorectal cancer,which warrants additional studies. © 2010 pasche et al; licensee biomed central ltd.
|
|
|
|
|
آدرس
|
division of hematology/oncology,university of alabama at birmingham,uab comprehensive cancer center,birmingham,al 35203, United States, section of hematology/oncology,university of wisconsin,school of medicine and public health,madison,wi 53792, United States, department of medicine,feinberg school of medicine,northwestern university,chicago,il 60611, United States, department of medicine,feinberg school of medicine,northwestern university,chicago,il 60611, United States, division of hematology/oncology,university of alabama at birmingham,uab comprehensive cancer center,birmingham,al 35203, United States, division of hematology/oncology,university of alabama at birmingham,uab comprehensive cancer center,birmingham,al 35203, United States, division of hematology/oncology,university of alabama at birmingham,uab comprehensive cancer center,birmingham,al 35203, United States, division of hematology/oncology,university of alabama at birmingham,uab comprehensive cancer center,birmingham,al 35203, United States, department of biostatistics,school of public health,university of alabama at birmingham,birmingham,al 35203, United States, department of biostatistics,school of public health,university of alabama at birmingham,birmingham,al 35203, United States, departments of medicine and community and of community and family medicine,dartmouth,hanover,nh 03755, United States, department of preventive medicine,keck school of medicine,university of southern california,los angeles,ca 90033, United States, department of medicine,feinberg school of medicine,northwestern university,chicago,il,united states,center for genetic medicine,feinberg school of medicine,northwestern university,chicago,il,united states,department of anthropology,northwestern university,evanston,il, United States
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|