MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma

Mir-106b is frequently up-regulated in various types of human cancer including laryngeal carcinoma. however the underlying mechanism of mir-106b involved in laryngeal carcinoma remains elusive. here we showed that reduction of mir-106b induced cell cycle g0/g1 arrest by targeting tumor suppressor rb in human laryngeal carcinoma cells. further,introducing rb cdna without 3'utr abrogated mir-106b-induced cell proliferation. finally,there was an inverse relationship between rb and mir-106b expression in laryngeal carcinoma tissues. to our knowledge,these data indicate for the first time that mir-106b directly regulate cell cycle by targeting rb in laryngeal carcinoma and that mir-106b could be potential therapeutic approaches for laryngeal carcinoma. © 2011 cai et al; licensee biomed central ltd.