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Effects of the tropical ginger compound,1-acetoxychavicol acetate,against tumor promotion in K5.Stat3C transgenic mice
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نویسنده
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batra v. ,syed z. ,gill j.n. ,coburn m.a. ,adegboyega p. ,digiovanni j. ,mathis j.m. ,shi r. ,clifford j.l. ,kleiner-hancock h.e.
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منبع
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journal of experimental and clinical cancer research - 2012 - دوره : 31 - شماره : 1
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چکیده
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The purpose of the current study was to determine whether a tropical ginger derived compound 1-acetoxychavicol acetate (aca),suppresses skin tumor promotion in k5.stat3c mice. in a two-week study in which wild-type (wt) and k5.stat3c mice were co-treated with either vehicle,aca,galanga extract,or fluocinolone acetonide (fa) and tetradecanoyl phorbol acetate (tpa),only the galanga extract and fa suppressed tpa-induced skin hyperproliferation and wet weight. none of these agents were effective at suppressing p-tyr705stat3 expression. however,aca and fa showed promising inhibitory effects against skin tumorigenesis in k5.stat3c mice. aca also suppressed phospho-p65 nf-κb activation,suggesting a potential mechanism for its action. © 2012 batra et al. licensee biomed central ltd.
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کلیدواژه
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Carcinogenesis; NF-κB; Squamous cell carcinoma; Stat3; TPA; Tropical ginger
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آدرس
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department of pharmacology,toxicology and neuroscience,louisiana state university,health sciences center,shreveport,la,united states,feist-weiller cancer center,shreveport,la, United States, department of biochemistry and molecular biology,louisiana state university,health sciences center,shreveport,la,united states,feist-weiller cancer center,shreveport,la, United States, department of biochemistry and molecular biology,louisiana state university,health sciences center,shreveport,la,united states,feist-weiller cancer center,shreveport,la, United States, department of pharmacology,toxicology and neuroscience,louisiana state university,health sciences center,shreveport,la,united states,feist-weiller cancer center,shreveport,la, United States, department of pathology,louisiana state university,health sciences center,shreveport,la,united states,feist-weiller cancer center,shreveport,la, United States, school of human ecology,university of texas,austin,tx, United States, department of cellular biology and anatomy,louisiana state university,health sciences center,shreveport,la,united states,feist-weiller cancer center,shreveport,la, United States, feist-weiller cancer center,shreveport,la,united states,department of medicine,louisiana state university,health sciences center,shreveport,la, United States, department of biochemistry and molecular biology,louisiana state university,health sciences center,shreveport,la,united states,feist-weiller cancer center,shreveport,la, United States, department of pharmacology,toxicology and neuroscience,louisiana state university,health sciences center,shreveport,la,united states,feist-weiller cancer center,shreveport,la, United States
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Authors
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