Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients

Background: hsp90-beta and annexin a1 were investigated as prognostic factors because of their apparent association with tumorigenesis. however,the effect of hsp90-beta and annexin a1 in lung cancer remains poorly understood. the expressions of hsp90-beta and annexin a1 in lung cancer and normal lung specimens were examined,and the relationships with respect to the clinico-pathological features and patient survival in lung cancer were analyzed. methods: the expression levels of hsp90-beta and annexin a1 were examined using immunohistochemistry,in-situ hybridization,and western blot. results: lung cancer tissues exhibited higher expression levels of hsp90-beta and annexin a1 than the normal tissues (p < 0.05),and the expression levels of the markers were significantly associated with the pathological grade and lymphatic invasion of lung cancer (p < 0.05). moreover,the upregulation of hsp90-beta and annexin a1 correlated with decreased survival (p < 0.05). conclusion: the upregulation of hsp90-beta and annexin a1 were associated with poor post-surgical survival time and lymphatic metastasis of lung cancer patients. moreover,the high expression of the markers was an independent predictor of poor outcomes. © 2012 biaoxue et al.; licensee biomed central ltd.