Tumorigenesis role and clinical significance of DJ-1,a negative regulator of PTEN,in supraglottic squamous cell carcinoma

Background: dj-1 can induce the tumor cell proliferation and invasion via down-regulating pten in many malignant tumors,and correlated to prognostic significance. however,the tumorigenesis role and clinical significance of dj-1 in supraglottic squamous cell carcinoma (sscc) is unclear. we aimed to evaluate the dj-1 the relationship between dj-1 and clinicopathological data including patient survival. methods. the expression of dj-1 and pten in ssccs (52) and adjacent non-cancerous tissues (42) was assessed by immunohistochemistry (ihc),and the relationship between dj-1 and clinicopathological data was analyzed. results: dj-1 was detected mainly in ssccs (88.5%) and less frequently in adjacent non-cancerous tissues (21.0%). pten expression was detected in 46.2% of ssccs and in 90.5% of adjacent non-cancerous tissues. dj-1 expression was linked to nodal status (p = 0.009),a highly significant association of dj-1 expression with shortened patient overall survival (5-year survival rate 88.0% versus 53.9%; p = 0.007; log rank test) was demonstrated. conclusions: our data suggested that dj-1 over-expression was linked to nodal status,and might be an independent prognostic marker for patients with sscc. © 2012 zhu et al.; licensee biomed central ltd.