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Ultrasound features of medullary thyroid carcinoma correlate with cancer aggressiveness: A retrospective multicenter study
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نویسنده
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trimboli p. ,giovanella l. ,valabrega s. ,andrioli m. ,baldelli r. ,cremonini n. ,rossi f. ,guidobaldi l. ,barnabei a. ,rota f. ,paoloni a. ,rizza l. ,fattorini g. ,latini m. ,ventura c. ,falasca p. ,orlandi f. ,crescenzi a. ,d'ambrosio f. ,cantisani v. ,romanelli f. ,negro r. ,saggiorato e. ,appetecchia m.
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منبع
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journal of experimental and clinical cancer research - 2014 - دوره : 33 - شماره : 1
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چکیده
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Background: poor prognosis of medullary thyroid cancer (mtc) with suspicious ultrasound (us) features has been reported. the aim of the study was to investigate the association between preoperative us presentation and aggressiveness features of mtc. also,us features of mtc were compared with those previously reported. methods: study group comprised 134 mtc from nine different centers. based on us presentation the nodules were stratified in at risk for malignancy (m-mtc) or probably benign (b-mtc) lesions. results: eighty nine (66.4%) m-mtc and 45 (33.6%) b-mtc were found. metastatic lymph nodes (p = 0.0001) and extrathyroid invasiveness (p < 0.0001) were more frequent in m-mtc. there was statistically significant correlation (p = 0.0002) between advanced tnm stage and m-mtc with an odds ratio 5.5 (95% ci 2.1-14.4). mean postsurgical calcitonin values were 224± 64 pg/ml in m-mtc and 51 ± 21 in b-mtc (p = 0.003). conclusions: this study showed that sonographically suspicious mtc is frequently associated with features of aggressiveness,suggesting that careful preoperative us of mtc patients may better plan their surgical approach. © 2014 trimboli et al.; licensee biomed central ltd.
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کلیدواژه
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Histology; Medullary thyroid cancer; Thyroid nodule; Ultrasonography
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آدرس
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section of endocrinology and diabetology,ospedale israelitico,rome,italy,department of nuclear medicine,thyroid centre,oncology institute of southern switzerland,bellinzona,switzerland,ospedale israelitico di roma,via fulda,14,rome, Italy, department of nuclear medicine,thyroid centre,oncology institute of southern switzerland,bellinzona, Switzerland, department of medical and surgical sciences,ospedale s. andrea,sapienza university,rome, Italy, endocrinologiaoggi,rome, Italy, endocrinology unit,regina elena national cancer institute,rome, Italy, u.o.c. endocrinology,ospedale maggiore,azienda usl,bologna, Italy, section of endocrinology and diabetology,ospedale israelitico,rome, Italy, section of pathology,ospedale israelitico,rome, Italy, endocrinology unit,regina elena national cancer institute,rome, Italy, endocrinology unit,regina elena national cancer institute,rome, Italy, endocrinology unit,regina elena national cancer institute,rome, Italy, endocrinology unit,regina elena national cancer institute,rome, Italy, section of endocrinology and diabetology,ospedale israelitico,rome,italy,department of experimental medicine,sapienza university,rome, Italy, section of endocrinology and diabetology,ospedale israelitico,rome, Italy, section of endocrinology and diabetology,ospedale israelitico,rome, Italy, internal medicine,ospedale s. sebastiano martire of frascati,rome, Italy, section of endocrinology,division of internal medicine,department of clinical and biological sciences,university of turin,torino, Italy, pathology unit,campus bio-medico university hospital,rome, Italy, department of radiology,oncology and anatomo pathology,sapienza university,rome, Italy, department of radiology,oncology and anatomo pathology,sapienza university,rome, Italy, department of experimental medicine,sapienza university,rome, Italy, division of endocrinology,ospedale v. fazzi,lecce, Italy, section of endocrinology,division of internal medicine,department of clinical and biological sciences,university of turin,torino,italy,service d'endocrinologie,pôle de médecine,centre hospitalier des escartons,briançon, France, endocrinology unit,regina elena national cancer institute,rome, Italy
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Authors
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