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High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma
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نویسنده
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liu w.-r. ,tian m.-x. ,jin l. ,yang l.-x. ,ding z.-b. ,shen y.-h. ,peng y.-f. ,zhou j. ,qiu s.-j. ,dai z. ,fan j. ,shi y.-h.
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منبع
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journal of experimental and clinical cancer research - 2014 - دوره : 33 - شماره : 1
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چکیده
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Background: the expression of 5-hydroxymethylcytosine (5-hmc) and isocitrate dehydrogenase 2 (idh2) is frequently downregulated in numerous cancers. 5-hmc and idh2 expression in hepatocellular carcinoma (hcc) has yet to be determined. methods. the immunohistochemical expression of 5-hmc and idh2 were analyzed in tissue microarrays containing samples from 646 patients who had undergone hepatectomy for histologically proven hcc. the prognostic value of 5-hmc and idh2 were evaluated by cox regression and kaplan-meier analyses. results: we discovered that low 5-hmc and idh2 expression was associated with malignant behaviors. low 5-hmc or idh2 expression alone and combined 5-hmc and idh2 expression were associated with lower overall survival (os) rates and higher cumulative recurrence rates. multivariate analysis indicated that 5-hmc or idh2 and 5-hmc/idh2 were independent prognostic indicators for os and time to recurrence (ttr),which was confirmed in an independent validation cohort. conclusions: 5-hmc and idh2 correlate with less aggressive tumor behavior in hcc. when 5-hmc and idh2 are considered together,they serve as a prognostic marker in patients with surgically resected hccs. © 2014 liu et al.; licensee biomed central ltd.
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کلیدواژه
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5-hydroxymethylcytosine; Hepatocellular carcinoma; Immunohistochemistry; Isocitrate dehydrogenase 2; Prognosis
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آدرس
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department of liver surgery,liver cancer institute,fudan university,180 fenglin road,shanghai 200032,china,key laboratory of carcinogenesis and cancer invasion of ministry of education,zhongshan hospital,fudan university,180 fenglin road,shanghai, China, department of liver surgery,liver cancer institute,fudan university,180 fenglin road,shanghai 200032,china,key laboratory of carcinogenesis and cancer invasion of ministry of education,zhongshan hospital,fudan university,180 fenglin road,shanghai, China, department of liver surgery,liver cancer institute,fudan university,180 fenglin road,shanghai 200032,china,key laboratory of carcinogenesis and cancer invasion of ministry of education,zhongshan hospital,fudan university,180 fenglin road,shanghai, China, department of liver surgery,liver cancer institute,fudan university,180 fenglin road,shanghai 200032,china,key laboratory of carcinogenesis and cancer invasion of ministry of education,zhongshan hospital,fudan university,180 fenglin road,shanghai, China, department of liver surgery,liver cancer institute,fudan university,180 fenglin road,shanghai 200032,china,key laboratory of carcinogenesis and cancer invasion of ministry of education,zhongshan hospital,fudan university,180 fenglin road,shanghai, China, department of liver surgery,liver cancer institute,fudan university,180 fenglin road,shanghai 200032,china,key laboratory of carcinogenesis and cancer invasion of ministry of education,zhongshan hospital,fudan university,180 fenglin road,shanghai, China, department of liver surgery,liver cancer institute,fudan university,180 fenglin road,shanghai 200032,china,key laboratory of carcinogenesis and cancer invasion of ministry of education,zhongshan hospital,fudan university,180 fenglin road,shanghai, China, department of liver surgery,liver cancer institute,fudan university,180 fenglin road,shanghai 200032,china,key laboratory of carcinogenesis and cancer invasion of ministry of education,zhongshan hospital,fudan university,180 fenglin road,shanghai,china,institutes of biomedical sciences,fudan university,shanghai, China, department of liver surgery,liver cancer institute,fudan university,180 fenglin road,shanghai 200032,china,key laboratory of carcinogenesis and cancer invasion of ministry of education,zhongshan hospital,fudan university,180 fenglin road,shanghai, China, department of liver surgery,liver cancer institute,fudan university,180 fenglin road,shanghai 200032,china,key laboratory of carcinogenesis and cancer invasion of ministry of education,zhongshan hospital,fudan university,180 fenglin road,shanghai, China, department of liver surgery,liver cancer institute,fudan university,180 fenglin road,shanghai 200032,china,key laboratory of carcinogenesis and cancer invasion of ministry of education,zhongshan hospital,fudan university,180 fenglin road,shanghai,china,institutes of biomedical sciences,fudan university,shanghai, China, department of liver surgery,liver cancer institute,fudan university,180 fenglin road,shanghai 200032,china,key laboratory of carcinogenesis and cancer invasion of ministry of education,zhongshan hospital,fudan university,180 fenglin road,shanghai, China
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Authors
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